Why Body Size Dogs Once VARIED?
Pet dogs have such a varied body sizes, from the size of a kitten up by goats. Among other mammals, dogs are probably the most varied body size. Why so?
This is an intriguing question Elaine A. Ostrander of the National Human Genome Research Institute (NHGRI) and other researchers. Because of these properties is derived, so the researchers studied the genetic properties of 3240 dogs from 143 different derivatives to find the mastermind of pure.
DNA test results turned out to show that the dogs a smallish have mutations in the same gene. However, mutations in these genes are not found in most of the big dogs, such as breed St. Bernards, Great Danes, and Irish wolhound.
A total of 14 dogs that are small, such as Portuguese water dog, chihuahua, fox terrier, poodle and Pomeranian, has the same DNA sequence in the gene which controls production of hormones like insulin growth factor 1 (IGF-1). This gene has been known to its role in regulating body growth in other organisms, such as mice and humans.
Gene Selection
"It shows that the derivative of a smallish dog came from the selection process on the same gene mutation," said Dr. Carlos Bustamante, one of the researchers from Cornell University in Ithaca, U.S.. The study further estimates that these mutations taking place since about 10 thousand years ago.
Genetically, all domestic dogs (pets) is a derivative of a wild wolf. The dog was first domesticated some 15 thousand years ago even though wolves have lived alongside humans for 400 thousand annually. In its development, genetic mutations become permanent after a similar derivative bred then spread through trade and together with human migration.
However, the same genetic sequence in IGF-1 gene is also found in several types of big dogs. That is, there are other factors that determine the size of the dog's body. "We know this new sebagain, but this finding is very important," said Ostrander who reported the latest findings in the journal Science.
He said that by studying the regulation of body growth, we can understand more clearly the formation of cancer and other diseases triggered by the growth process is wrong. Variation contained in the dog's body into a very good basis for studying variations that occur in the human body.
According to K. Gordon Lark, another researcher from the University of Utah, the dog has 200 to 300 diseases that also affects humans, such as high blood pressure, cancer and low immunity. Dogs are also living in the same environment with humans, so if there conditions that trigger this defect, the process is similar between the human body with the dog's body.
"So, if we can handle it on the dog, it is a fantastic leap," he said.
Source: AP / BBC
maybe you're interested in the article Before Deciding Own Dogs
This is an intriguing question Elaine A. Ostrander of the National Human Genome Research Institute (NHGRI) and other researchers. Because of these properties is derived, so the researchers studied the genetic properties of 3240 dogs from 143 different derivatives to find the mastermind of pure.
DNA test results turned out to show that the dogs a smallish have mutations in the same gene. However, mutations in these genes are not found in most of the big dogs, such as breed St. Bernards, Great Danes, and Irish wolhound.
A total of 14 dogs that are small, such as Portuguese water dog, chihuahua, fox terrier, poodle and Pomeranian, has the same DNA sequence in the gene which controls production of hormones like insulin growth factor 1 (IGF-1). This gene has been known to its role in regulating body growth in other organisms, such as mice and humans.
Gene Selection
"It shows that the derivative of a smallish dog came from the selection process on the same gene mutation," said Dr. Carlos Bustamante, one of the researchers from Cornell University in Ithaca, U.S.. The study further estimates that these mutations taking place since about 10 thousand years ago.
Genetically, all domestic dogs (pets) is a derivative of a wild wolf. The dog was first domesticated some 15 thousand years ago even though wolves have lived alongside humans for 400 thousand annually. In its development, genetic mutations become permanent after a similar derivative bred then spread through trade and together with human migration.
However, the same genetic sequence in IGF-1 gene is also found in several types of big dogs. That is, there are other factors that determine the size of the dog's body. "We know this new sebagain, but this finding is very important," said Ostrander who reported the latest findings in the journal Science.
He said that by studying the regulation of body growth, we can understand more clearly the formation of cancer and other diseases triggered by the growth process is wrong. Variation contained in the dog's body into a very good basis for studying variations that occur in the human body.
According to K. Gordon Lark, another researcher from the University of Utah, the dog has 200 to 300 diseases that also affects humans, such as high blood pressure, cancer and low immunity. Dogs are also living in the same environment with humans, so if there conditions that trigger this defect, the process is similar between the human body with the dog's body.
"So, if we can handle it on the dog, it is a fantastic leap," he said.
Source: AP / BBC
maybe you're interested in the article Before Deciding Own Dogs
Hello, nice to come to your blog!
dogs said... May 8, 2011 at 10:51 AM
thank you .... hopefully all the information on my blog can be a little help
sonynhn said... May 11, 2011 at 7:33 AM
thank you.... hopefully all the information on my blog can be a little help
sonynhn said... May 11, 2011 at 7:44 AM
[...] Why Body Size Dogs Once VARIED? [...]
Why Body Size Dogs Once VARIED? « bestinfoguide said... May 27, 2011 at 11:00 PM
Post a Comment